The University of Georgia

Tamar Tsertsvadze
Associate Professor
Doctor
Department of Natural Sciences
School of Science and Technology

Education

Iv. Javakhishvili Tbilisi State University - BioMedicine - Bachelor - 09/01/1999 - 07/17/2003

Iv. Javakhishvili Tbilisi State University - Faculty of Exact and Natural Sciences - Doctor - 09/01/2009 - 06/15/2015

Publications

Kardava L, Kartvelishvili M, Tsagareishvili M, Baloiani D, Okujava R, Gabunia KH, Amaglobeli N, Sereda L, Burjanadze L, Tsertsvadze T, Girdaladze D, Poraqishvil N; Regulatory phenotype of CD4 perforin expressing T cells in B -cell chronic lymphocytic leukaemia . Proceedings of the Georgian Academy of Sciences, 2006, 32 - 2006

Kulikova N, Okujava R, Janikashvili N, Gabunia Kh, Mitskevichi N, Tsertsvadze T, Tsagareishvili P, Ghirdaladze D, Porakishvili N. Toll-like receptors expression profile in patients with B cell Chronic Lymphocytic Leukaemia (B-CLL). Proceedings of the Georgian Academy of Sciences. 2006; 32.3:523- 530 - 2006

Kulikova N, Tsertsvadze T, Tsagareishvili P,Sereda L, Tevzadze M, Kardava L, Gachechiladze N, Lukhumaidze M, Ghirdaladze M, Amaglobeli N, Porakishvili N. Association between seropositivity for cytomegalovirus (CMV) and CD4+ Cytotoxic T cells expansions in patients with B-cell chronic lymphocyte leukaemia (B-CLL) and healthy controls. Proceedings of the Georgian Academy of Sciences, 2009. 7. 3- 4, 41-46 - 2009

Porakishvili Nino, Vispute Ketki, Rajakaruna Nadeeka, Andrew Steele, Kulikova Nina, Tsertsvadze Tamar, Clark Edward A., Rai Kanti R., Nathwani Amit, Damle Rajendra N., Chiorazzi Nicholas and Lydyard, Peter M. Re-wiring of sIgM-mediated signaling by CD180-toll-like receptor in CLL. Molecular Medicine. 2015;21:46-57. - 2015

Tsertsvadze T, Mitskevich N, Ghirdaladze D, Porakishvili N.Correlation of the exression of CD32 and CD180 receptors on CLL cells and MEC1 Cell Line. Georgian Medical News. 2015; 2(240): 56- 59. - 2015

sertsvadze T, Mitskevich N, Ghirdaladze D, Porakishvili N. Aberrant expression of Fcg receptors and toll like receptor CD180 on monocytes from patients with chronic lymphocytic leikaemia. Georgian Medical News, 2015, 2(239): 35-38. - 2015

Tsertsvadze T, Mitskevich N, Bilanishvili A, Girdaladze D, Porakishvili N.PHAGOCYTOSIS AND EXPRESSION OF FCg-RECEPTORS AND CD180 ON MONOCYTES IN CHRONIC LYMPHOCYTIC LEUKEMIA. Georgian Med News. (270):88-93 - 2017

Nunu Mitskevich, Tamar Tsertsvadze, Kakha Mchedlishvil, Georgi Guruli. Modulation Of Antitumor Immune Response In Mouse Cancer Model. Georgian Med News. 2017, 2017 (266):39-47. - 2017

Nina Porakishvili, Sergey Krysov, Emanuela Volpi, Uzma Sayed, Kristi-na Zaitseva, Ketki Vispute, Tamar Tsertsvadze, Ani Bilanishvili, Nunu Mitskevich, Amit Nathwani, Nicholas Chiorazzi, Peter Lydyard Patterns of CD180 expression and function in the peripheral blood and lymph nodes of patients with chronic lymphocytic leukaemia (CLL) LEUKEMIA & LYMPHOMA, Publisher TAYLOR & FRANCIS LTD Vol 61 pg 139-141 - 2020

Nunu Mitskevich, Tamar Tsertsvadze, Natela Melikidze, Mariam Sukhiashvili, Ketevan Machavariani N Mitskevich, T Tsertsvadze, N Melikidze, M Sukhiashvili, K Machavariani Nunu Mitskevich, Tamar Tsertsvadze, Kakha Mchedlishvil, Georgi Guruli Nunu Mitskevich, Tamar Tsertsvadze, Kakha Mchedlishvil, Georgi Guruli Tsertsvadze T, Mitskevich N, Bilanishvili A, Girdaladze D, Porakishvili N. Tsertsvadze T, Mitskevich N, Ghirdaladze D, Porakishvili N. Expression of T-helper Cytokines by γδT Cell Subsets in Respiratory Allergic Diseases. The role of gamma delta T cells in immunopathogenesis of respiratory allergies 2020 Journal of Allergy and Clinical Immunology Vol- 2020 - 2020

Tamar Tsertsvadze, Nunu Mitskevich, Irine Datikashvili-David , Darejan Ghirdaladze, Nina Porakishvili. Attachment of Chronic Lymphocytic Leukaemia (CLL) cells by autologous polymorphonuclear neutrophils (PMNs) mediated by Bispecific anti- CD19/CD64antibody Georgian Med News, 01 Nov 2020, (308):118-123 - 2020

J. MARKHULIA , SH. KEKUTIA , V. MIKELASHVILI, L. ALMASY, L. SANEBLIDZE, T. TSERTSVADZE , N. MAISURADZE , N. LELADZE , M. KRIECHBAUM Stable Aqueous Dispersions of Bare and Double Layer Functionalized Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications Materials Science-Poland DOI: 10.2478/msp-2021-0028 - 2021

Elene Davitashvili , George Burjanadze , Marine Koshoridze , Nana Koshoridze, Tamar Tsertsvadze , Nunu Mitskevich , Omar Tsintsadze , Guram Karazanashvili , Revaz Solomonia Galactose specific lectins from prostate tissue with different pathologies: biochemical and cellular studies Molecular Biology Reports. 2021 Nov 5. doi: 10.1007/s11033-021- 06894-w. - 2021

Mitskevich Nunu., Tsertsvadze Tamar., Maisuradze Nino., Datuashvili Maia., Zeyad Abdulrazzaq Ahmed Khaled., Qobalia Guranda., Mekokishvili Lally. CORRELATION OF CD4+Т LYMPHOCYTES ACTIVATION WITH INTERLEUKIN IL-9, IL-17, IL- 22 PROFILES IN THE PERIPHERAL BLOOD OF PATIENTS WITH PLAQUE PSORIASIS Georgian Med News . 2021 Mar; (312):75-78. - 2021

N. Maisuradze, J. Markhulia, Sh. Kekutia, T. Tsertsvadze, V. Mikelashvili, L. Saneblidze, N. Leladze, M. Kriechbaum and L. Almasy Evaluation of doxorubicin-loaded iron oxide nanoparticles synthesis and in vitro cytotoxicity on 4T1 tumorigenic epithelial cell lines NANOTECH / BIOTECH FRANCE 2021 AND JOINT VIRTUAL CONFERENCES - 2021

Tekle Kalichava1 , Tamar Tsertsvadze1 , Nunu Mitskevich1 , Zaza Avaliani2 , Peter Maldwyn Lydyard3 , Mark Bodman Smith4 , Nina Porakishvili5 PHENOTYPIC PATTERNS OF VΔ1 AND VΔ2 ΓΔ T CELL SUBSETS IN PATIENTS WITH ACTIVE PULMONARY TUBERCULOSIS Asthma Allergy Immunology - 2022

lene Davitashvili1 *, George Burjanadze1 , Natalia Dachanidze1 , Marine Koshoridze1 , Nana Koshoridze1 , Tamar Tsertsvadze2 , Nunu Mitskevich2 , Omar Tsintsadze3 , Guram Karazanashvili4 and Revaz Solomonia5 Some Biological Effects of Galactose- Specific Lectins from Prostate Tissue with Different Pathologies in Tumor Cells Model In vitro Journal of Urology and Research - 2022

Kurtis Edwards; Peter M. Lydyard; Nina Kulikova, Tamar Tsertsvadze; Emanuela V. Volpi; Nicholas Chiorazzi; Nino Porakishvili The role of CD180 in haematological malignancies and inflammatory disorders Molecular Medicine volume29, Article number:97( 2023) - 2023

Jano Markhulia 1, *, Shalva Kekutia 1 , Vladimer Mikelashvili 1 , Liana Saneblidze 1 , Tamar Tsertsvadze 2 , Nino maisuradze 1,2 , Nino Leladze 2 , Zsolt Czigány 3 and László Almásy 3, * Synthesis, characterization, and in vitro cytotoxicity evaluation of doxorubicin- loaded magnetite nanoparticles on triple- negative breast cancer cell lines Pharmaceutics . 2023 Jun 17;15(6):1758. doi: 10.3390/pharmaceutics15061758. - 2023

yed; Tamar Tsertsvadze; Lara De Deyn; Amit Nathwani; John G Gribben; Sergey Krysov; Emanuela V Volpi; Peter M Lydyard; Nino Porakishvili MD-1 downregulation contributes to reduced cell surface CD180 expression in CLL Leukemia Research - 2024

Dr. Tamar Tsertsvadze, PhD with high profile scientific publications. She has a good deal of expertise in participating, coordinating and supervising scientific projects. She has been awarded the Soros’ Foundation Award (2002), Scholarship of the World Federation of Scientist (2013-2014), as well as a special scholarship to attend the EAACI Congress 2018 held in Munich, German. In 2019, she won the Ivane Beritashvili Scholarship in Medical and Health Sciences. In 2021 she won the Shota Rustaveli National Science Foundation Scholarship for outstanding scientific activity and field development and for exceptional advances in science. Twice she has been awarded the Young scientists research grant by the National Science Foundation (Georgia) - Project YS15_2.3.1_106 (2015-2017) and Project YS_2018_042 (2018-2020), both researches were devoted to study the role of CD180 in pathogenesis of CLL. Dr. Tsertsvadze has a Certificate in Laboratory Medicine and therefore has a good insight into both clinical and fundamental aspects of CLL. She is an accomplished flow cytometrist and has been working with a wide variety of Flow Cytometers such as BD, Cyan and she is also familiar with the operational system of FacsCalibur. For several years Dr Tsertsvadze has acted as a Senior Flow Cytometry operator of the Diagnostic center affiliated to TSU and provided diagnostic services for the Childhood leukemia clinic. Dr. Tamar Tsertsvadze is also a dedicated and skilled researcher, the focus of her investigation mainly being in leukaemia.